Another Piece of the p27Kip1 Puzzle
نویسنده
چکیده
How extracellular signals communicate with the cell cycle is poorly understood. In this issue, two papers address this problem by reporting phosphorylation of the cyclin-dependent kinase inhibitor p27Kip1 on a tyrosine residue by nonreceptor tyrosine kinases, which decreases p27 stability. This new mechanism could explain how cells enter the cell cycle from a quiescent state.
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ورودعنوان ژورنال:
- Cell
دوره 128 شماره
صفحات -
تاریخ انتشار 2007